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URL of PIC server: http://crick.mbu.iisc.ernet.in/~PIC

Why PIC?

Protein Interactions calculator is used to explore interactions within a protein or between proteins. All the interactions and bonds can be seen in a single site and also the identified interactions/bonds between residues can be visualized using a RasMol and Jmol interface.

Highlights:

The PIC server computes various interactions within a protein (intra protein Interactions) or between proteins (protein-protein Interactions) in a complex. Such as,

1. Disulphide bonds
2. Hydrophobic residues Interactions
3. Ionic interactions
4. Hydrogen bonds
5. Aromatic–aromatic interactions
6. Aromatic–sulphur interactions
7. Cation–pi interactions
8. Calculating distance of the residue from the surface of the protein (using solvent accessibility program) and recognizing various interactions at that point.
9. Calculating the depth of a residue and recognizing various interactions, that are formed near the surface or deep inside.

All the interactions and bonds can be seen in a single site and also the identified interactions/bonds between residues can be visualized using a RasMol and Jmol interface with the interactions highlighted.

Input Format to PIC server:

PIC server accepts atomic coordinate set of a protein structure in the standard Protein Data Bank (PDB) format.

Links:
PubMed Link: PIC: Protein Interactions Calculator